Shouting from far away: three poems about living with speechlessness

We present three poems written from personal experience of living with primary progressive non-fluent aphasia (primary progressive apraxia of speech). The poems provide a window on this illness 'from the inside', and vividly illustrate how intellect and inner life may survive strikingly intact, even after speech is lost

Impact of time to appropriate therapy on mortality in patients with vancomycin-intermediate Staphylococcus aureus infection

Despite the increasing incidence of vancomycin-intermediate Staphylococcus aureus (VISA) infections, few studies have examined the impact of delay in receipt of appropriate antimicrobial therapy on outcomes in VISA patients. We examined the effects of timing of appropriate antimicrobial therapy in a cohort of patients with sterile-site methicillin-resistant S. aureus (MRSA) and VISA infections. In this single-center, retrospective cohort study, we identified all patients with MRSA or VISA sterile-site infections from June 2009 to February 2015. Clinical outcomes were compared according to MRSA/VISA classification, demographics, comorbidities, and antimicrobial treatment. Thirty-day all-cause mortality was modeled with Kaplan-Meier curves. Multivariate logistic regression analysis (MVLRA) was used to determine odds ratios for mortality. We identified 354 patients with MRSA (n = 267) or VISA (n = 87) sterile-site infection. Fifty-five patients (15.5%) were nonsurvivors. Factors associated with mortality in MVLRA included pneumonia, unknown source of infection, acute physiology and chronic health evaluation (APACHE) II score, solid-organ malignancy, and admission from skilled care facilities. Time to appropriate antimicrobial therapy was not significantly associated with outcome. Presence of a VISA infection compared to that of a non-VISA S. aureus infection did not result in excess mortality. Linezolid use was a risk for mortality in patients with APACHE II scores of ≥14. Our results suggest that empirical vancomycin use in patients with VISA infections does not result in excess mortality. Future studies should (i) include larger numbers of patients with VISA infections to confirm the findings presented here and (ii) determine the optimal antibiotic therapy for critically ill patients with MRSA and VISA infections

It's not what you play, it's how you play it: timbre affects perception of emotion in music.

Salient sensory experiences often have a strong emotional tone, but the neuropsychological relations between perceptual characteristics of sensory objects and the affective information they convey remain poorly defined. Here we addressed the relationship between sound identity and emotional information using music. In two experiments, we investigated whether perception of emotions is influenced by altering the musical instrument on which the music is played, independently of other musical features. In the first experiment, 40 novel melodies each representing one of four emotions (happiness, sadness, fear, or anger) were each recorded on four different instruments (an electronic synthesizer, a piano, a violin, and a trumpet), controlling for melody, tempo, and loudness between instruments. Healthy participants (23 young adults aged 18-30 years, 24 older adults aged 58-75 years) were asked to select which emotion they thought each musical stimulus represented in a four-alternative forced-choice task. Using a generalized linear mixed model we found a significant interaction between instrument and emotion judgement with a similar pattern in young and older adults (p < .0001 for each age group). The effect was not attributable to musical expertise. In the second experiment using the same melodies and experimental design, the interaction between timbre and perceived emotion was replicated (p < .05) in another group of young adults for novel synthetic timbres designed to incorporate timbral cues to particular emotions. Our findings show that timbre (instrument identity) independently affects the perception of emotions in music after controlling for other acoustic, cognitive, and performance factors

Music, memory and mechanisms in Alzheimer’s disease

This scientific commentary refers to ‘Why musical memory can be preserved in advanced Alzheimer’s disease’, by Jacobsen et al. (doi:10.1093/brain/awv135)

Time relations and structural-stratigraphic patterns in ophiolite accretion, west central Klamath Mountains, California

New geochronological data and published structural and stratigraphic data show that two distinctly different ophiolitic assemblages formed in general proximity to one another at nearly the same time and were subsequently imbricated along a regional thrust zone. The Josephine ophiolite constitutes a complete oceanic crust and upper mantle sequence which lies within the western Jurassic belt of the Klamath province. Within the study area the Josephine ophiolite was formed by seafloor spreading at about 157 m.y. before present. It was immediately covered by a thin pelagic and hemipelagic sequence which grades into a thick flysch sequence, both of which comprise the Galice Formation. The Galice flysch was derived from volcanic arc and uplifted continental margin orogenic assemblages. A major nonvolcanic source for the Galice flysch appears to have been the western Paleozoic and Triassic belt of the Klamath province exposed to the east. Proximal volcanic arc activity migrated to the site of the Josephine-Galice section by 151 m.y. and is represented by numerous dikes and sills which intrude the ophiolite and Galice Formation. The Preston Peak ophiolite is a polygenetic assemblage consisting of (1) a pre-mid-Jurassic tectonitic peridotite-amphibolite substrate which represents disrupted and unroofed basement of the western Paleozoic and Triassic belt and (2) an upper mafic complex which was intruded through and constructed above the tectonite substrate at about 160 m.y. The mafic complex consists primarily of diabase hypabyssal rocks that are overlain by diabase-clast breccia and hemipelagic deposits. A major arc-plutonic complex was emplaced into the Preston Peak ophiolite in at least two pulses at 153 and 149 m.y. Major phases of this complex consist of wehrlite, gabbro, pyroxene diorite, and hornblende diorite. The Josephine ophiolite is interpreted as the remnants of interarc basin crust. The Preston Peak ophiolite is interpreted as either a primitive remnant arc complex or a rift edge facies for the Josephine interarc basin. The Galice Formation represents a submarine fan complex that was built on juvenile crust of the Josephine basin floor. During the time interval of 153 to 149 m.y. the locus or arc magmatism migrated to an area which included the interarc basin floor and the remnant arc or basin edge. The basin shortly thereafter closed by convergent tectonics during the Nevadan orogeny resulting in the imbrication of the Josephine and Preston Peak ophiolites and their superimposed arc assemblages. The transition from seafloor spreading generation of Josephine ophiolite to its tectonic accretion by convergence and basin closure occurred within 5 to 10 m.y. The process of rifting and ophiolite formation in series with convergence and ophiolite accretion is considered an important mechanism for generating and displacing allocthonous terranes in the Klamath Mountains-Sierra Nevada region, and perhaps throughout the western cordillera

An Optimal Application of Swine Effluent in Texas and Oklahoma Panhandle Determined by Bayesian Stochastic Dynamic Programming

Swine Effluent Irrigation, Environmental Economics and Policy,

Thinking eyes: visual thinking strategies and the social brain

The foundation of art processes in the social brain can guide the scientific study of how human beings perceive and interact with their environment. Here, we applied the theoretical frameworks of the social and artistic brain connectomes to an eye-tracking paradigm with the aim to elucidate how different viewing conditions and social cues influence gaze patterns and personal resonance with artworks and complex imagery in healthy adults. We compared two viewing conditions that encourage personal or social perspective taking-modeled on the well-known Visual Thinking Strategies (VTS) method-to a viewing condition during which only contextual information about the image was provided. Our findings showed that the viewing conditions that used VTS techniques directed the gaze more toward highly salient social cues (Animate elements) in artworks and complex imagery, compared to when only contextual information was provided. We furthermore found that audio cues also directed visual attention, whereby listening to a personal reflection by another person (VTS) had a stronger effect than contextual information. However, we found no effect of viewing condition on the personal resonance with the artworks and complex images when taking the random effects of the image selection into account. Our study provides a neurobiological grounding of the VTS method in the social brain, revealing that this pedagogical method of engaging viewers with artworks measurably shapes people's visual exploration patterns. This is not only of relevance to (art) education but also has implications for art-based diagnostic and therapeutic applications

The Speech-to-Song Illusion Is Reduced in Speakers of Tonal (vs. Non-Tonal) Languages.

The speech-to-song illusion has attracted interest as a probe of the perceptual interface between language and music. One might anticipate differential speech-to-song effects in tonal vs. non-tonal languages, since these language classes differ importantly in the linguistic value they assign to tones. Here we addressed this issue for the first time in a cohort of 20 healthy younger adults whose native language was either tonal (Thai, Mandarin) or non-tonal (German, Italian) and all of whom were also fluent in English. All participants were assessed using a protocol designed to induce the speech-to-song illusion on speech excerpts presented in each of the five study languages. Over the combined participant group, there was evidence of a speech-to-song illusion effect for all language stimuli and the extent to which individual participants rated stimuli as "song-like" at baseline was significantly positively correlated with the strength of the speech-to-song effect. However, tonal and non-tonal language stimuli elicited comparable speech-to-song effects and no acoustic language parameter was found to predict the effect. Examining the effect of the listener's native language, tonal language native speakers experienced significantly weaker speech-to-song effects than non-tonal native speakers across languages. Both non-tonal native language and inability to understand the stimulus language significantly predicted the speech-to-song illusion. These findings together suggest that relative propensity to perceive prosodic structures as inherently linguistic vs. musical may modulate the speech-to-song illusion

fMRI Evidence for a Cortical Hierarchy of Pitch Pattern Processing

Pitch patterns, such as melodies, consist of two levels of structure: a global level, comprising the pattern of ups and downs, or contour; and a local level, comprising the precise intervals that make up this contour. An influential neuropsychological model suggests that these two levels of processing are hierarchically linked, with processing of the global structure occurring within the right hemisphere in advance of local processing within the left. However, the predictions of this model and its anatomical basis have not been tested in neurologically normal individuals. The present study used fMRI and required participants to listen to consecutive pitch sequences while performing a same/different one-back task. Sequences, when different, either preserved (local) or violated (global) the contour of the sequence preceding them. When the activations for the local and global conditions were contrasted directly, additional activation was seen for local processing in right planum temporale and posterior superior temporal sulcus (pSTS). The presence of additional activation for local over global processing supports the hierarchical view that the global structure of a pitch sequence acts as a “framework” on which the local detail is subsequently hung. However, the lateralisation of activation seen in the present study, with global processing occurring in left pSTS and local processing occurring bilaterally, differed from that predicted by the neuroanatomical model. A re-examination of the individual lesion data on which the neuroanatomical model is based revealed that the lesion data equally well support the laterality scheme suggested by our data. While the present study supports the hierarchical view of local and global processing, there is an evident need for further research, both in patients and neurologically normal individuals, before an understanding of the functional lateralisation of local and global processing can be considered established

Structural neuroanatomy of face processing in frontotemporal lobar degeneration

Impairments of face processing occur frequently in frontotemporal lobar degeneration (FTLD) but the neuroanatomical basis for these deficits has seldom been studied systematically. Here a prospective voxel based morphometry study is described addressing the neuroanatomy of two key dimensions of face processing—face identification and facial emotion recognition—in a single cohort of 32 patients with FTLD (19 with frontal variant and 13 with temporal variant FTLD). For the FTLD group as a whole, face identification was positively associated with grey matter in the right anterior fusiform gyrus while recognition of angry expressions was positively associated with grey matter in the bilateral insula cortex. FTLD provides a perspective on the neuroanatomy of face processing that is complementary to focal lesion and normal functional imaging work